Issues playing and automating from synth

Hi, from one day to another i’m not able to play through my synths but only from the pyramid and so not able to make automation live too.
Is anybody enough kind to explain me why?

I’m pretty sure all the settings are right.

a) Load a song where it is working and save the track setting. Then go back to that particular one and open it. It would take the previous track setting.

b) I’ve got a blank track with working midi thru and out. Anytime it happens you just go back and use it. A bit of contradiction with a) but it really works.